Friday, 26 December 2014

Metformin in Patients With Type 2 Diabetes and Kidney Disease A Systematic Review (JAMA)

"Available evidence supports cautious expansion of metformin use in patients with mild to moderate chronic kidney disease, as defined by estimated glomerular filtration rate, with appropriate dosage reductions and careful follow-up of kidney function."

Inzucchi SE, Lipska KJ, Mayo H, et al. Metformin in patients with type 2 diabetes and kidney disease: A systematic review. JAMA 2014;312:2668–75. doi:10.1001/jama.2014.15298

The review was published in JAMA by a team lead by Professor Silvio Inzucchi of Yale University School of Medicine.

"The researchers said they are petitioning the FDA to update its guidelines, to make metformin available to more than 2.5 million Americans with type 2 diabetes."


  1. No news there then. Personally use until eGFR 30 and/or Creatinine of 150

  2. Agree no news really but good to have a recent review to refer others too.