tag:blogger.com,1999:blog-1651191617949674054.post5087781368187765191..comments2024-03-17T17:29:31.245+00:00Comments on Differential Diagnosis: SGLT2 inhibitors for diabetesDean Jenkinshttp://www.blogger.com/profile/07988740182662829798noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-1651191617949674054.post-30073407818898455422012-04-13T17:37:11.657+01:002012-04-13T17:37:11.657+01:00When insulin was discovered, the aim of the treatm...When insulin was discovered, the aim of the treatment was to eliminate renal glycosuria. Kids with type 1 diabetes perfected the skills of testing their urine for the presence of sugar in camps. Prolonged absence of urine sugar was celebrated as a great achievement. <br /><br />Now we have come a full circle. We are still desperately trying to normalize the blood glucose levels by various means while the centenary of insulin discovery is around the corner. SGLT2 inhibitors reduce the renal threshold for glucose excretion, thereby improving the blood glucose levels. What was hailed as a success in the late 1920s [disappearance of urine glucose]is getting purposefully reversed by a drug. Prolonged glycosuria invites infections also.<br /><br />Almost all the drugs which got introduced in the last decade have been implicated in cancer. Bladder cancer with pioglitazone, Medullary thyroid cancer with liraglutide, breast/Bladder cancer with dapagliflozin... the list may not end here. On the contrary, there is evidence that metformin may protect patients with type 2 diabetes against some of the cancers.Anonymoushttps://www.blogger.com/profile/00663622895766869933noreply@blogger.comtag:blogger.com,1999:blog-1651191617949674054.post-66071146743058606802012-04-12T00:39:50.180+01:002012-04-12T00:39:50.180+01:00Theoretically a good concept but infection rate is...Theoretically a good concept but infection rate is high and due to short duration of studies concerns about cancer remain. Sorry but found the fourth reference a bit funny! improves glycemic control over 28 days! what next 28 hours?Anonymousnoreply@blogger.com